What is CBD oil? It is an extract of natural ingredients from hemp that can help treat neuralgia, anxiety, epilepsy, inflammation, stress and many other wonderful effects that you cannot imagine without. Read this article in its entirety!
What is CBD oil?
CBD Oil Cannabis Indica and Cannabis Sativa is a derivative of the Cannabis Indica and Cannabis Sativa plants, which includes both the cannabis plant and the industrial hemp plant.
CBD oil is a collection of benign active ingredients that can help with chronic pain, reduce anxiety, improve eating, along with activities like marijuana, but without affecting your mental state. CBD can also help treat some serious diseases such as epilepsy, depression, autism and aid in the palliative treatment of various types of cancer.
CBD is an abbreviation for Cannabidiol, one of the two active ingredients in the cannabis plant with the most health effects. The other is tetrahydrocannabinol (THC).
THC is what causes the psychoactive effects of marijuana – in other words, the high effect. CBD oil is generally THC-free, although you can still find very small amounts that can't cause unwanted effects in products on the market.
CBD oil contains a collection of tonic and healing botanicals combined with a carrier oil such as coconut oil or hemp seed oil. Bottled CBD oil is called tincture (CBD tincture) or simply CBD oil (CBD oil) and is sold in different strengths and volumes.
There is also the form CBD capsules, CBD gum and CBD spray under the tongue.
This article will go over CBD's uses, possible side effects, and what you need to know when looking buy CBD
So what is CBD used for?
CBD has no clear specific mechanism of action:
Unlike THC, CBD does not bind strongly to cannabinoid receptors in the brain. These receptors are molecules to which THC binds to produce psychoactive effects for recreational purposes.
Instead, CBD affects other receptors, like the opioid receptors that control pain. It also affects the glycine receptor that controls serotonin – a substance in the brain known as the “happy hormone.”
Proponents of CBD claim that CBD oil can treat a variety of health problems, including:
- Chronic pain
- Drug addiction treatment.
- Increased intraocular pressure
- High Blood Pressure
- Muscle spasms
- Parkinson disease
- Picky eaters.
More research on CBD has been and is being done as it gains more and more interest from the public. However, there are only a handful of clinical studies on the effects of CBD oil.
As a result, some of the medical claims below are more supported by researchers than others.
“If you're thinking about taking CBD to treat a health problem, talk to your healthcare provider to make sure it's an appropriate option for you.
A 2015 review of studies in the Journal of Neurotherapeutics suggests that CBD can help treat anxiety disorders. *
The study's authors report that CBD has a powerful anxiety-reducing effect in animals.
In most studies, low doses of CBD (10mg/1kg, 1mg/1kg, or less) improved some symptoms of anxiety, but high doses (100mg/kg or more) were close. like no effect.
The way CBD works in the brain may account for this. At low doses, CBD can act like the surrounding molecules that normally bind to receptors, which "activate" their signaling.
However, at higher doses, too much activity around the receptor can cause the opposite effect. This will negate the beneficial effects of CBD.
There are not many clinical studies observing the anxiety-relieving effects of CBD in humans. A handful of which was a 2019 study published in the Brazilian Journal of Psychiatry. *
In this study, 57 men took CBD or a placebo (sugar tablets) before a public speaking event. The researchers measured anxiety levels based on blood pressure and heart rate. They also use a reliable mood-testing method called the Visually Analogous Mood Scale (VASM).
Men who took 300mg of CBD oil showed less anxiety than those who took a placebo. Interestingly, those taking 100mg or 600mg did not have the same results.
CBD oil has the potential to help people with substance use disorders, according to a review in the journal Substance Abuse. *
Statistical review of 14 publicly available studies. Nine of these studies observed effects in animals, and five observed effects in humans.
Researchers report that CBD shows promise in treating people with addictions to opioids, cocaine, or addictive psychostimulants.
However, CBD affects each drug in a different way.
For example, CBD without THC does not help with the symptoms of opioid withdrawal. On the other hand, it reduced drug-seeking behaviors in users of cocaine, methamphetamine, and other similar drugs.
Some experts suggest that CBD may help treat marijuana and nicotine dependence, but more research is needed.
Doctors may prescribe medical marijuana for people with severe pain who cannot respond to medical treatment, such as those with terminal cancer. There is some evidence that CBD plays a role in these benefits.
An interesting study in 2012 was published in the Journal of Experimental Medicine. The researchers injected mice with chemicals that cause inflammation. Then they gave them CBD.
Rats given CBD had less inflammation and neuropathic pain (pain due to nerve damage) *
“Scientists believe that CBD relieves neuropathic pain by binding to receptors that control the rate at which nerve signals are transmitted between nerve cells in the brain.
However, there are not too many studies testing the use of CBD in the treatment of chronic pain in humans. The studies that have been done have almost always included THC. This makes it difficult to isolate the individual effects of CBD.
High Blood Pressure
CBD oil may reduce the risk of heart disease by reducing high blood pressure in people, according to a 2017 study in JCI Insight. *
According to the study, nine healthy men took either 600mg of CBD or the same dose of a placebo. People taking CBD had lower blood pressure before and after stressors like exercise or extreme cold.
The study also looked at stroke volume (the amount of blood that remains in the heart after each heartbeat). The stroke volume in those who took CBD was lower than in the placebo group, meaning their hearts were beating more efficiently.
Research suggests that CBD oil could be an effective complementary therapy for people whose high blood pressure is affected by stress and anxiety.
However, there is no evidence that CBD oil can treat high blood pressure or prevent it in people at risk when standing alone. While stress can complicate high blood pressure, it doesn't cause the problem by itself.
In June 2018, the US Food and Drug Administration (FDA) approved Epidiolex – an oral CBD solution. 
Epidiolex is used to treat two rare types of seizures in children younger than 2 years of age: Dravet Syndrome and Lennox-Gastaut Syndrome. These are very rare genetic disorders that cause lifelong seizures that occur from the first years of life.
Apart from these two disorders, the effectiveness of CBD in the treatment of epilepsy is unclear. Even with Epidiolex, it is not clear whether the anticonvulsant effect is from CBD or another factor. 
There is some evidence that CBD interacts with anticonvulsants such as Onfi (clobazam) and increases blood levels. Still, more research is needed.
Bottom Line: CBD oil can help relieve stress, anxiety, seizures, and stimulant withdrawal. But taking a higher dose doesn't always have a stronger effect. Another thing is that so much of the research on CBD has been done on animals, so it's hard to say that these effects also work in humans.
Potential side effects
Clinical studies have shown that CBD oil can cause side effects. The severity and type of side effects may vary from person to person
Side effects include: 
- Change your appetite.
- Mood change
- Dry mouth
CBD oil may also increase liver enzymes (a sign of hepatitis). People with liver disease should consult their healthcare provider before taking CBD oil and use it with caution. Blood liver enzyme levels should be checked regularly.
Do not take CBD oil if you are pregnant or breastfeeding. The American Academy of Pediatrics advises pregnant women to stay away from marijuana because of the potential risks to the developing fetus. 
Although the effects of CBD by itself are unclear in this case, CBD can cross the placenta.
Do not drive or operate heavy machinery while taking CBD oil as some of these oils contain THC. This is especially important when you are just starting treatment or using a new brand.
Interactions with drugs
CBD oil can interact with a number of medications, including some used to treat epilepsy.
Cytochrome P450 (CYP450) is an enzyme in the body that breaks down certain drugs. But CBD can block the normal action of CYP450. CBD oil can make some medications you take stronger than you need or make them less effective.
Potentially interacting drugs with CBD include:
Antiarrhythmic drugs such as quinidine
- Anticonvulsants such as Tegretol (carbamazepine) and Trileptal (oxcarbazepine)
- Antifungal medications such as Nizoral (ketoconazole) and Vfend (voriconazole)
- Antipsychotics such as Orap (pimozide)
- Atypical antidepressants such as Remeron (mirtazapine)
- Benzodiazepines such as Klonopin (clonazepam) and Halcion (triazolam)
- Immunosuppressants such as Sandimmune (cyclosporine)
- Macrolide antibiotics such as clarithromycin and telithromycin
- Migraine medications such as Ergomar (ergotamine)
- Opioid pain relievers such as Duragesic (fentanyl) and alfentanil
- Drugs based on rifampin used to treat tuberculosis
To avoid interactions, tell your healthcare provider and pharmacist what medicines you are taking. This includes prescription, over-the-counter, herbal, or recreational drugs.
Many of these interactions are mild and do not require a change in treatments. Others may ask you to alternate medications you're taking or to split doses over several hours.
Of course, never change your medication regimen without your doctor's approval.
Summary: You may experience nausea, diarrhea, or dizziness when taking CBD oil. Do not take CBD oil if you are pregnant or breastfeeding. Additionally, CBD oil affects the way your body breaks down certain medications, so talk to your healthcare provider if you're taking any.
Dosage and Preparation
There are no guidelines for the proper use of CBD oil. CBD oil is usually taken by putting one or more drops under the tongue and keeping it there for 30 to 60 seconds without swallowing.
There is no “correct” dose of CBD for each person. Depending on your needs and what you are treating, the daily dose may range from 5 mg to 25 mg.
The tricky part is calculating the exact amount of CBD per milliliter of oil. Some tinctures have concentrations of 1,500 mg per 30 mL, while others have concentrations of 3,000 mg/mL (or more).
Most oils come in a 30 ml (mL) bottle with a dropper cap.
“How to calculate CBD dosage
To determine the correct dose of CBD, keep in mind that each drop of oil is approximately 0.05ml of solution. This means that a 30ml bottle of CBD oil will have around 600 drops. If the product concentration is 1500mg per mL, one drop will contain approximately 2.5mg of CBD.
Capsules, gummies, and sprays are easier to dose, although they are often more expensive.
What do you need to look for?
CBD oil comes in many different forms. The isolate contains only CBD, but the fully extracted oil includes several other components from the cannabis plant. Includes proteins, flavonoids, terpenes and chlorophyll.
Alternative medicine experts believe that these compounds offer more important health benefits, but there is no clear evidence to support this.
Keep in mind that CBD oil is mostly unregulated, so there's no guarantee that a product is safe, effective, or what it claims to be on the packaging.
A 2017 study reported that only 31% CBD products sold online were true to their packaging. Most contain less CBD than advertised, while 21% has significant amounts of THC.
Here are a few tips to help you find the best CBD oil:
- Buy American: Domestically produced CBD oil is probably safer. (article published in the US)
- Choose organic: U.S. Department of Agriculture (USDA) certified brands are less likely to expose you to pesticides and other harmful chemicals.
- Read product labels: Even if you choose whole oils, don't assume every ingredient on a product label is natural. There may be preservatives, flavorings, or thinners that you don't want or need. If you don't recognize an ingredient, ask your distributor what it is or check online.
Are CBD Oil and Hemp Oil the same thing?
Not necessarily. While some use these names interchangeably, hemp oil can also be used for hemp seed oil, which is used for cooking, food manufacturing, and skin care products.
CBD oil is made from the leaves, stems, buds and flowers of the Indica or Cannabis sativa plant and must contain less than 0.3% THC. Hemp oil is made from the seeds of the Cannabis plant and does not contain THC.
Unlike the THC found in cannabis, CBD oil does not make you high. It contains a chemical called cannabidiol that may help relieve stress, anxiety, smoking cessation, and nerve pain.
However, CBD oil may change the way your body breaks down certain medications. This can make the drug stronger or weaker, which can be dangerous. Talk to your doctor before you use CBD oil, especially if you take any medications or have liver disease.
- What is CBD?
- CBD Health Benefits
- Difference Between CBD Oil and Hemp Oil
- How is CBD oil made?
- 3 tips to get the correct dose of CBD
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CBD oil, as long as it is extracted from hemp, is legal in most countries worldwide, as it contains low levels of THC (under 0.3%) – this is the compound that makes you high, and which is illegal in most countries. Hemp is considered a controlled plant but can be used in skin care products, natural beauty products, clothing and cooking ingredients. You can easily search for hemp products on major e-commerce stores such as lazada, shopee, tiki... or organic food stores. See more.
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